Tuesday, 16th September International Association for Breast Cancer Research 2014

• Genomic markers of predisposition and progression - Ian Campbell
• Challenges of implementing biomarkers in breast cancer - Sandra O'Toole
• TMEM and Menacalc as prognostic makers for breast cancer - Thomas Rohan
• HER2 signaling post-translationally activates c-MYC to drive HER2+ breast cancer - Rosalie Sears

• Modeling metastatic progression in patient-derived xenograft lines of ER+ breast cancer - Hallgeir Rui
• R-spondin-3 is an oncogene driving the development of mammary tumors distinctive from Wnt1-induced tumors - John Hilkens
• STAT3 promotes an immunosuppressive tumour microenvironment - William Muller
• Elf5-forced lactation induces lung metastasis in the MMTV-PyMT mouse mammary tumour model   - David Gallego Ortega

• Benefits of a new generation genetic signature in the diagnostic of breast cancer and impact of intrinsic subtypes on the clinical strategy - Chana Lotan

• C/EBPdelta is a candidate tumor suppressor whose protein expression is induced by the estrogen receptor - Daniel Mendoza Villanueva
• Pro-apoptotic Bim suppresses breast tumor cell metastasis and is a target gene of SNAI2 - Delphine Merino
• Long-range regulation of HOTAIR reveals a network of transcription factors associated with reduced survival in breast cancer - Michael Milevskiy
• CBFß: A novel regulator of mammary gland development and breast carcinogenesis - Anne-Marie M. Mooney
• ALK1-negative anaplastic large cell lymphoma of the breast from a non-prosthesis cyst - Christopher Mulligan
• Oestrogen receptor alpha (ERα) is a novel substrate of mechanistic target of rapamycin (mTOR) in human breast cancer - Leigh Murphy
• Role of RANKL signalling in the development of BRCA1-associated breast cancer - Emma Nolan
• Null mutation in C1q impairs tumourigenesis in MMTV-PyMT and DMBA-induced mammary cancer mouse models - Siti Noor Din
• Investigating the role of ncRNAs in breast cancer associated DNA methylation - Korinne Northwood
• Jersey regulates mammary development and plays a key role in human breast carcinogenesis - Samantha Oakes
• Runx2 regulates mammary cell fate and drives breast cancer progression - Thomas W. Owens
• Genome-wide microRNA analyses of mouse and human mammary epithelial subpopulations - Bhupinder Pal
• Old system, new norms: Redefining a new and more meaningful relationship between Ki67 and mitosis - Vaishali Pannu
• Clearing the fog: A novel Ki67-mitosis classifier enables deeper segmentation of the “grey zone” Nottingham Grade II patients - Vaishali Pannu
• An integrated Ki67-mitosis classifier fine tunes the Nottingham grading system - Vaishali Pannu
• A novel method to quantify centrosome amplification yields a putative risk-predictive biomarker in breast cancer - Vaishali Pannu
• Determining the role of ageing in involution-associated mammary tumourigenesis - Sara Pensa
• Expression and function Of Elf5 splice variants in the molecular subtypes of breast cancer - Catherine Piggin
• C-C chemokine receptor 5 (CCR5) is required for tumour angiogenesis - Prue N. Plummer
• SOX10 is an independent marker of poor prognosis in triple-negative and basal-like breast cancer - Ashwini Raghavendra
• A transcriptional regulatory map of ELF5 action in luminal breast cancers - Daniel Roden
• Tumour genotype, not cell-of-origin, dictates tumour phenotype - Alasdair Russell
• Molecular mechanism of efficient treatment of resistant breast cancer using mitochondria-targeting tamoxifen - Karishma Sachaphibulkij
• Identification of microRNAs that function downstream of Brca1 - Gurveen Sandhu
• Genomic and transcriptomic landscapes of brain metastases from breast cancer - Jodi M. Saunus*
• Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastases - Jodi M Saunus
• Stem and progenitor cell division kinetics during postnatal mouse mammary gland development - Mona Shehata
• Robust detection of cell surface markers in paraffin embedded tissue: Use of chemical antibodies in the diagnosis of breast cancer - Sarah Shigdar
• The role of epithelial to mesenchymal plasticity in driving the invasive capacity of ‘lobular-like’ tumour cell differentiation in breast cancer - Peter Simpson
• A neural-immune axis in the tumor microenvironment remodels lymphatic vasculature to drive metastasis - Erica Sloan
• Chemokines from breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in MCF7 breast cancer cells - Patsy Soon
• Chemokines from breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in MCF7 breast cancer cells - Patsy Soon
• Development and characterisation of a 3D in vitro tri-culture model of normal breast: a tool for cancer initiation studies - Valerie Speirs
• Hypermethylation of the estrogen-responsive enhanceosome is a fundamental feature of endocrine resistant breast cancer - Andrew Stone
• Sphingosine-1-phosphate receptors regulate sensitivity of breast cancer cells to TNFalpha-induced programmed necrosis - Olga A Sukocheva
• Dysfunctional Aging Mammary Stem Cells - Lu-Zhe Sun
• Inhibitor of Differentiation 4 (ID4) maintains mammary stem cell homeostasis and identifies a subset of poor-prognosis basal-like breast cancers with a stem-like phenotype - Alexander Swarbrick
• Tumour-infiltrating T cells and RANK/RANKL expression in locally-advanced and metastatic breast cancer - Elizabeth Thomas
• Integrated Target Discovery in the EMPathy Breast Cancer Network - Multidimensional Analysis of Epithelial Mesenchymal Plasticity (EMP) in Experimental Systems. - Erik (Rik) W2 Thompson
• An MDA-MB-231 cell line derived from lymph node metastasis has lower proliferation but higher metabolism - Yan Tu
• Targeting the ASCT2 glutamine uptake pathway suppresses cell growth in truple-negative breast cancer - Michelle van Geldermalsen
• Contrasting roles for Met overexpression and activation in predicting radiotherapy response in breast cancer - Cynthia Veenstra
• Targeting STAT3 Activity in Breast Cancer - Matthew S Wake
• Breast cancer-secreted miRNA destroys the natural barriers in the host to promote metastasis - Shizhen Emily Wang
• An aptamer based siRNA delivery system targeting tumourigenic cells in a chemo-resistant breast cancer model - Sarah Shigdar
• Breast cancer metastasis is supported via three major mechanisms independent of the canonical DNA repair function of RAD51.   - Adrian Wiegmans
• Anticancer Activity of Raw and Boiled Aqueous Extract of Cassava Leaves (Manihot esculenta Crantz) on MCF-7 Cell Line - Fatma Zuhrotun Nisa
• Uncovering the mechanisms that regulate cell survival in cancer via manipulating the function of myeloid cell leukaemia 1 (MCL-1) - Adelaide Young

• Regulation of lineage commitment and genomic stability - Christine Watson
• Cell polarity proteins during normal mammary gland development and tumorigenesis - Senthil Muthuswamy
• Regulation of breast cancer metabolism and epigenetics by the tyrosine kinase C-SRC - Harvey Smith

The conference dinner will be located at the International College of Management Sydney

151 Darley Rd, Manly NSW 2095