Geoffrey Greene
Dr. Greene studies female steroid hormones and the mechanisms by which they regulate development, proliferation, and survival in hormone responsive tissues and cancers. He developed the first antibodies against the estrogen receptor (ERα), which were essential for developing clinical assays to predict appropriate therapy and prognosis in breast cancers. He also jointly cloned and sequenced the human ERα cDNA, leading to identification of specific hormone receptor domains that explain structure/function of this class of nuclear hormone receptors. In addition, he has solved multiple 3D structures of ERα LBD and used this information to elucidate the mechanisms by which SERMs like tamoxifen and raloxifene function as antagonists. Dr. Greene is currently studying the mechanisms by which somatic ERα mutations result in endocrine therapy resistance in metastatic breast cancers and how to overcome this resistance.
Abstracts this author is presenting:
