Invasive lobular carcinoma (ILC) accounts for up to 15% of all invasive breast cancers. ILC show a distinctive phenotype of diffuse growth, with increased stromal composition and a ‘single file’ pattern of invasion. The loss of E-cadherin expression is considered an archetypal feature of ILC. The gene encoding E-cadherin, CDH1, has been reported to be mutated in 50-90% of ILC cases. With chromosomal loss on 16q, encompassing the CDH1 locus, found in 90% of ILCs. Most ILCs (~95%) are Oestrogen Receptor (ER) positive and tend towards a better prognosis in the short term. However, ILCs demonstrate a peculiar metastatic organotropism and tend to spread to the peritoneum and gynaecological organs, rather than the usual sites of lung, liver and bone. While some studies have attempted to characterize the differences between invasive lobular and ductal carcinomas using gene expression arrays, overall the tumour numbers have been low and few identified pathways have been consistently identified between studies. The oncogenic drivers of the lobular phenotype have thus far remained elusive. We have assembled a large, fresh frozen ILC cohort with samples sourced from the Australian Breast Cancer Tissue Bank (ABCTB) and our Brisbane Breast Bank (BBB). The cohort has clinical data and has undergone rigorous pathology review. We present an integrated molecular landscape of ILCs with an assessment of genome-wide gene expression analysis, SNP Copy Number Variation analysis and a mutation analysis (targeted amplicon panel of 22 genes). We also present a comparison with publically available databases.